Critique A Research Study
Sepsis Prevention Management and treatment
Sepsis Prevention Management and treatment 9
Sepsis Prevention Management and Treatment
Nursing Science and the Research Process
01/20/2021
Association of care bundle for early Sepsis Management with Mortality among with hospital
Authors; Robert H. Brook, Daniel Z. Uslan & Jack Needleman
Tittle (year); Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis, 2020
Methodology; cohort study
Sample; 6404 patients selected through questionnaires
Study type: retrospective cohort study
Results; among the 6404 participants, 3535 men had hospital-onset sepsis associated to reduced mortality.
Conclusions; broad-spectrum intravenous antibiotic treatment is related to mortality of patients with sepsis.
Recommendations; the current sepsis quality parameters should be refined
Requirements and technologies improving sepsis management
Authors; Bryan M. Gale and Kendall K. Hall,
Tittle (year): The Use of Patient Monitoring Systems to Improve Sepsis Recognition and Outcomes: A Systematic Review
Methodology; Secondary Data Analysis
Sample: 19 peer-reviewed articles selected from CINAHL, MEDLINE, and Cochrane through systematic review
Study type: literature review
Results; there was a mixture of study results but the evidence for process measure showed improvement outside the ICU
Conclusions: current literature is mixed on the effectiveness of automated sepsis PMSs on sepsis recognition
Recommendations: more testing on the effects of systems should be conducted
Surviving sepsis guidelines
Authors; Andrew Rhodes, Laura E Evans, Waleed Alhazzani
Tittle (year): Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Methodology: surveys
Sample: 55 international experts selected to attend a conference
Study type: randomized
Results: Surviving Sepsis Guideline was strongly recommended by 32 members, 39 weak recommendations.
Conclusions: recommendations based on evidence on acute management of sepsis is based on improved outcomes for patients who are critically ill
Recommendations; more recommendations should be sort
Sepsis alert in Emergency D
Authors; ROBERT GAUER, MD, and DAMON FORBES
Tittle (year): Sepsis: Diagnosis and Management, 2020
Methodology; literature review
Sample; 8 peer reviewed articles selected and analysed
Study type: literature review
Results; fluid resuscitation is mandatory in the early management of sepsis
Conclusions: the guidelines published in 2016 are controversial
Recommendations; the 2016 guidelines should be revised to avoid future failures
Effectiveness of early management Bundle for sever sepsis
Authors; Robert H. Brook, Daniel Z. Uslan & Jack Needleman
Tittle (year); Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis, 2020
Methodology; cohort study
Sample; 6404 patients selected through questionnaires
Study type: retrospective cohort study
Results; among the 6404 participants, 3535 men had hospital-onset sepsis associated to reduced mortality.
Conclusions; broad-spectrum intravenous antibiotic treatment is related to mortality of patients with sepsis.
Recommendations; the current sepsis quality parameters should be refined
Recognition and management of sepsis
Authors; Greg Bleakley, Mark Cole
Tittle (year); Recognition and management of sepsis: the nurse’s role, 2020
Methodology;
Sample; 4 peer-reviewed articles from PubMed
Study type: literature review
Results; most nurses require training and updating of guidelines on intervention of sepsis
Conclusions; nurses should different strategies to ensure quick actions and reduce the death of sepsis students
Recommendations; nurses should be furnished with clinical guidelines to allow prompt actions on sepsis
Managing sepsis effectively with national early warning score
Authors; Joanne Jones
Tittle (year); Managing sepsis effectively with national early warning scores and screening tools, 2017
Methodology; Secondary Data Analysis
Sample; 6 peer-reviewed articles
Study type: literature review
Results; national early warning scores and screening tools increase the effective management of sepsis
Conclusions; national early warning scores and screening tools should be employed in sepsis management
Recommendations; More screening tools should be researched and applied
Adults’ sepsis in. pre-hospital environment
Authors; Mark Langley, Carrie Langley
Tittle; Adult sepsis in a pre-hospital environment, 2013
Methodology; Secondary Data Analysis
Sample; 9 peer-reviewed journals
Study type: literature review
Results; high level of care at the onset of sepsis reduces mortality
Conclusions; care of patients with sepsis should be started at the onset of the illness
Recommendations; ratified guidelines should be introduced for pre-hospital professionals in management of sepsis
Sepsis and chronic wounds
Authors; Richard White, Steven LA Jeffery, Keith Cutting
Tittle (year); Sepsis and chronic wounds: The extent of the issue and what we should we be aware of, 2015
Methodology; Secondary data analysis
Sample; 3 peer-reviewed articles
Study type: literature review
Results; sepsis results in fatal wounds, shock and organ failure if not treated early
Conclusions; sepsis should be treated early to avoid wounds and multiple organ failure
Recommendations; clinicians should also be aware of the implications of over-diagnoses
Treatment of sepsis
Authors; Chanu Rhee, Travis M Jones, Yasir Hamad, Anupam Pande
Tittle (year); Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals, 2019
Methodology; focus group
Sample; 568 randomly selected from 6 hospitals in US
Study type: cohort
Results; 198 hospitalized patients died due to sepsis, 92 due to progressive cancer, 29 due to dementia, 63 due to solid cancer, 31 due to hematologic cancer
Conclusions; although sepsis is the main cause of mortality, most deaths are associated to underlying conditions
Recommendations; innovations in prevention should are important in reduction of sepsis-associated deaths
Sepsis mortality
Authors; Chanu Rhee, Travis M Jones, Yasir Hamad, Anupam Pande
Tittle (year); Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals, 2019
Methodology; focus group
Sample; 568 randomly selected from 6 hospitals in US
Study type: cohort
Results; 198 hospitalized patients died due to sepsis, 92 due to progressive cancer, 29 due to dementia, 63 due to solid cancer, 31 due to hematologic cancer
Conclusions; although sepsis is the main cause of mortality, most deaths are associated to underlying conditions
Recommendations; innovations in prevention should are important in reduction of sepsis-associated deaths
Nursing early detection of sepsis
Authors; Vincent X Liu , Gabriel J Escobar , Rakesh Chaudhary , Hallie C Prescott
Tittle (year); Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization, 2018
Methodology; Retrospective study.
Sample; 14,658 Kaiser Permanente Northern California sepsis hospitalizations and 31,369 Veterans Health Administration sepsis hospitalizations
Study type: randomized
Results; in Kaiser Permanente Northern California 2648 patients and 3,858 Veterans Health Administration patients had a presepsis encounter
Conclusions; more than 45% of sepsis patients had seen a clinician before being admitted
Recommendations; the presepsis encounters provide an opportunity to improve treatment and risk reduction
Sepsis due to nosocomial pneumonia
Authors; David J Murphy, Peter J Pronovost
Tittle (year); Reducing preventable harm: comment on “Clinical and economic outcomes attributable to health care-associated sepsis and pneumonia, 2010
Methodology; secondary data analysis
Sample; 5 peer-reviewed articles from PubMed
Study type: literature review
Results; more than 60% of sepsis patient face economic hardships due to sepsis and pneumonia
Conclusions; sepsis and pneumonia’s preventable harm should include both clinical and economic outcomes
Recommendations; more research should be carried out on reducing preventable harm
Hospitalization cost due to sepsis
Authors; Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta
Tittle (year); Sepsis among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018, 2020
Methodology; secondary data analysis
Sample; Medicare beneficiaries in 2012 to 2018 analysed
Study type: literature review
Results; the total cost of sepsis control increased from $17,792,657,303 to $22,439,794,212
Conclusions; sepsis is still highly expensive to control and treat
Recommendations; more funds should be availed to control sepsis and sepsis shock
Sepsis alert
Authors; POWERS, KELLY A.; BURCHELL, PATRICIA
Tittle (year); Sepsis alert: Avoiding the shock, 2010
Methodology; secondary data analysis
Sample; a peer-reviewed journal from PubMed
Study type: literature review
Results; more than 45% sepsis patients suffer from shock
Conclusions: sepsis shock can be avoided through a proactive approach
Recommendations; more improvements should be made in identifying and controlling sepsis shock
Delay in administration of 2nd dosage of AX after admission
Authors; Daniel Leisman , Victor Huang, Qiuping Zhou, Jeanie Gribben, Andrea Bianculli,
Tittle (year); Delayed Second Dose Antibiotics for Patients Admitted from the Emergency Department with Sepsis: Prevalence, Risk Factors, and Outcomes, 2017
Methodology; focus group
Sample; 828 sepsis cases from a single health centre
Study type: Retrospective
Results; 272 of the 828 sepsis cases had a more than 25% delay
Conclusions; patients under a shorter half-life pharmacotherapy have main second dose delays
Recommendations; identify and realise ways of lowering major second dose delays
Medication of choice
Authors; Aaron J Heffernan, Rebecca A Curran , Kerina J Denny, Fekade B Sime
Tittle (year); Ceftriaxone dosing in patients admitted from the emergency department with sepsis, 2020
Methodology; focus groups
Sample; All patients in an emergency department and with sepsis
Study type: randomized
Results; 1-g once-daily dose does not achieve the minimum therapeutic ceftriaxone exposure in > 90% patients with a creatinine clearance ≥ 60 mL/min.
Conclusions; 2-g once-daily dose is appropriate for infected patients with a creatinine clearance ≤ 140 mL/min.
Recommendations; clinical trials in future should address how optimization of ceftriaxone dose improves sepsis treatment.
Epidemiology
Authors; Carly J Paoli, Mark A Reynolds, Meenal Sinha, Matthew Gitlin, Elliott Crouser
Tittle (year); Epidemiology and Costs of Sepsis in the United States-An Analysis Based on Timing of Diagnosis and Severity Level, 2018
Methodology; observational study
Sample; 2,566,689 sepsis cases in 2010 to 2016 admission in a medical centre
Study type: cohort
Results; a mortality of 12.5% was recorded for sepsis but the severity varied with a range of 5.6%, 14.9%, and 34.2% for patients without organ dysfunction, severe sepsis, and septic shock.
Conclusions; lowest severity of sepsis led to increased burden and cost
Recommendations; methods of identifying and treating sepsis should be innovated
