1. Appraise and debate the sampling methods and determine the quality of the sampling procedures in reducing bias. Consider the following questions:
    • Was the sampling method and inclusion/exclusion criteria adequate to reduce sampling bias?
    • Are the sample characteristics representative of the target population?
    • Was the sample size adequate?
    • Was there a decrease in sample size?  If so, did the researchers identify decreases early and attempt to reduce the impact?  Was a decrease, if any, adequately explained by the researchers?